Vice Health Minister Kim Gang-lip said the outbreak had entered "a serious new phase".
Many of the new cases are linked to a hospital and to a religious group near the south-eastern city of Daegu, authorities have said.
Two patients in South Korea have died so far and there are fears the number will rise.
Daegu and nearby Cheongdo - where the hospital is situated - have been declared "special care zones" and the streets of Daegu are reported to be largely abandoned.
South Korea has now reported the largest number of confirmed infections outside China - 76,288 cases including 2,345 deaths - and the outbreak on the Diamond Princess cruise ship off the coast of Japan which has seen more than 600 cases.
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